You Damn Kid! (http://www.youdamnkid.com/bytitle.html)
What: The memoirs of the creator's (Owen Dunne) childhood growing up in a bickering, yet caring Catholic family.
Why: Dunne could've easily fallen in to same trap as fellow slice-of-life webcomic creators, Jeph Jacques (Questionable Content) and Starline X Hodge (Candi) by relaying on something popular (like Starline's anime-style art or Jacques' indie band name-dropping) and sassy Future Merchandizing Items to make their stories interesting; but Dunne doesn't. He trusts his material and it ends up being funny as a result. The art is pretty simple, but it fits the comic and has a nice 1950's feel to it.
Problems: Some of the stips aren't as good as others.
Perry Bible Fellowship (http://www.pbfcomics.com/)
What: A bunch of gag strips with a twist ending.
Why: While PBF has it's share of potty and sex humor, a lot of the stips are just very clever with a very dark sense of humor that sometimeas require a little thought to get. Not to mention that Gurewitch is an excellent artist who can change styles on a dime and do it well.
Problems: There's times when Gurewitch does cross the lines of good taste or get a little too mean and some of the strips fail (the really early ones aren't as funny or well drawn.)
Girl Genius (http://www.girlgeniusonline.com/)
What: The adventures of a Spark (a mad scientist-type of inventor) on an alternate earth with steampunk qualities.
Why: I've just started reading this one and so far, I like it. Usually fantasy webcomics annouy me because some creators think the only thing they have to do is say it's a fantasy world, give it an anime style or wackiness and to hell with explaining the world itself or trying to make it interesting. I'm glad that Phil and Kaja Fogilo don't do this (so far) while still having some nice touches And Phil Foglio is a pretty good artist especally with backgrounds.
Problems: At times, I just don't like the way Phil does faces and my opinion may or may not change as I read more. (And it takes a while to get into.)